Could Anti-Diabetic Drugs Fuel The Spread Of Cancer?

| May 10, 2016

People with diabetes are at increased risk of developing cancer, as I mentioned previously here. The risks of pancreatic, colorectal, liver, bladder, breast and endometrial cancers all go up. So it is disturbing, to say the least, that a recent study showed a class of diabetes drugs called DPP-4 inhibitors could fuel the spread of colon and liver cancers to other parts of the body. Especially since the same drugs have already been found to trigger the development of acute pancreatitis and pancreatic cancer, as I wrote here.

The DPP-4 inhibitors, also known as gliptins, include sitagliptin (Januvia), saxagliptin (Onglyza) and vildagliptin (Galvus). There are also several commonly-prescribed combinations of gliptins with another diabetes drug, metformin. DPP-4 inhibitors work by blocking the action of an enzyme called DPP-4, which breaks down the hormone incretin. This has the effect of blocking the release of glucose from the liver while increasing insulin production, so lowering blood sugar levels.

In a study with mice, researchers found that DPP-4 inhibitors didn’t appear to increase the incidence of colon and liver tumours. But in mice that had human tumour cells implanted into them, these drugs did boost the ability of the resulting tumours to ‘metastase’ – that is to say, to migrate and invade other parts of the body.1 When this happens, of course, the outlook in human patients is invariably poor.

In a typically understated way, the researchers suggest that DPP-4 inhibitor drugs “may need to be administered with caution in diabetic patients with cancer”. Personally I would like to see these dangerous drugs completely banned. As well as being linked to cancers, sitagliptin and saxagliptin have been shown to raise the risk of potentially deadly heart failure by 25 per cent, as I reported here.

Wouldn’t it be incredible if there were a safe, natural remedy that could lower blood sugar levels as effectively as standard diabetes drugs? And what if it could also reduce the risks of cancer and heart failure instead of raising them; and as a bonus, slash other cardiovascular risks by reducing levels of dangerous blood fats and LDL-cholesterol? Well, this is no dream – this amazing substance is real and I’ll be telling you about it in my next blog post.

Wishing you the best of health,

Martin Hum
PhD DHD Nutritionist
for Real Diabetes Truth

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1. Wang H, Liu X, Long M et al. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Sci Transl Med. 2016; 8(334):51. 

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