More Actos Dangers And Side Effects

| April 23, 2016

In my last blog post, I reported on a new study linking the use of diabetes drug Actos with a 63 per cent higher risk of bladder cancer. But that isn’t the only risk that goes up when you start taking this drug. You are also putting yourself in line for several other serious health problems, including heart failure, a potentially fatal condition in which the heart is unable to pump blood around the body strongly enough.

In a 2015 review of diabetes medications and cardiovascular risks, researchers found that Actos and its close relative Avandia (rosiglitazone) were associated with a 42 per cent increase in heart failure risk, as I wrote here. We all know that having diabetes raises cardiovascular risks, so the last thing you want is for your blood sugar-lowering medication to increase those risks!

That’s not all. A 2014 study in Taiwan found that Actos use doubles the risk of chronic kidney disease, another frequent complication of diabetes. It can also cause osteoporosis and more than doubles the risk of suffering a hip fracture, according to a study carried out at Dundee University. Other research has concluded that Actos more than trebles the risk of an eye disease called macula oedema, which leads to blurred vision.

And that’s on top of a list of side effects as long as your arm, including:

  • Weight gain
  • Headache
  • Muscle pain
  • Unusual fatigue
  • Cold or flu-like symptoms
  • Sinusitis
  • Cough
  • Sore throat
  • Dry mouth
  • Toothache

Actos is a drug that should be immediately withdrawn. But its manufacturer, Takeda pharmaceuticals, is taking a “wait and see” approach. Waiting to see how many more vulnerable diabetes patients have to die before their time. Waiting to see how many more research papers need to be published before the regulatory bodies finally recognise that the dangers of Actos far outweigh its benefits. Because Actos means big money – and that’s all that counts with Big Pharma.

Knowing about the risks and side effects of diabetes drugs is one step to self-empowerment and putting yourself in control of your health. A newly published study has shown that diabetes patients who are empowered in this way have lower blood sugar levels and better health than those who are given standard education about their condition. More on this in my next blog post.

Wishing you the best of health,

Martin Hum
PhD DHD Nutritionist
for Real Diabetes Truth

Did you find this information useful?

If you enjoyed this content or found it useful and educational, please share this article with your friends and family.

Bear in mind we are not addressing anyone’s personal situation and you should rely on this for informational purposes only. Please consult with your own physician before acting on any recommendations contained herein.


  1. Udell JA, Cavender MA, Bhatt DL, Chatterjee S, Farkouh ME, Scirica BM. Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol. 2015; 3(5):356-366.
  1. Lee MY, Hsiao PJ, Yang YH, Lin KD, Shin SJ. The association of pioglitazone and urinary tract disease in type 2 diabetic Taiwanese: bladder cancer and chronic kidney disease. PLoS One. 2014; 9(1):e85479.
  1. Colhoun HM, Livingstone SJ, Looker HC et al. Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs. Diabetologia. 2012; 55(11):2929-2937.
  1. Idris I, Warren G, Donnelly R. Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes. Arch Intern Med. 2012; 172(13):1005-1011.
Print Friendly

Tags: , , ,

Category: Diabetes Drugs

Comments are closed.